Saude Cardiovascular

Omega-3 Fatty Acids – Health Benefits

omega 3 food sources

Omega-3 fatty acids are essential nutrients for the normal functioning of the body. As the human body cannot produce sufficient amounts of these fatty acids, it is necessary to obtain them through diet or food supplements.

Omega-3s play an important role in cell structure and are especially concentrated in organs such as the brain and eyes. Adequate intake contributes to the maintenance of normal brain function, vision, cardiovascular health, and overall body balance.

What are Omega-3 fatty acids?

Omega-3 fatty acids are a type of polyunsaturated fat considered essential for human health.

The term "essential" means that the body needs these nutrients but cannot produce them in sufficient quantities, making it necessary to obtain them through diet.

Fatty acids are composed of chains of carbon, hydrogen, and oxygen and can be divided into two main groups: saturated fats and unsaturated fats.

Omega-3s belong to the group of polyunsaturated fats, considered important when consumed as part of a varied and balanced diet.

What types of Omega-3 fatty acids exist?

There are three main types of Omega-3:

EPA (eicosapentaenoic acid) – primarily found in fatty fish, it is a marine-derived Omega-3 studied for its role in maintaining cardiovascular health and balancing the body's natural inflammatory processes.

DHA (docosahexaenoic acid) – primarily found in fish and algae, it is an important structural component of brain and eye cells.

ALA (alpha-linolenic acid) – is the plant-based form of Omega-3, present in foods such as seeds, nuts, and vegetable oils.

Although the body can convert a small amount of ALA into EPA and DHA, this conversion is limited. Therefore, it is important to include dietary sources of EPA and DHA, such as fish or algae, in a balanced diet.

What are the health benefits of Omega-3 fatty acids?

Omega-3 fatty acids play important roles in the body, forming part of the structure of cell membranes and contributing to the normal functioning of various systems.

Scientific research has studied the role of Omega-3s in different areas:

Cardiovascular health

Omega-3s can contribute to maintaining normal triglyceride levels in the blood and support the normal functioning of the heart and blood vessels.

Brain and cognitive function

DHA contributes to the maintenance of normal brain function and is an important component of nerve cells.

Eye health

DHA is present in high concentrations in the retina and contributes to the maintenance of normal vision.

Skin health

Omega-3s are part of the structure of skin cell membranes and contribute to their maintenance and balance.

Joint health

Omega-3s have been studied for their role in joint comfort and mobility.

Balance of inflammatory processes

Omega-3s participate in the production of molecules involved in regulating the body's natural inflammatory processes.

What are the dietary sources of Omega-3?

The main dietary sources of EPA and DHA are fatty fish, including:

  • Salmon;
  • Sardine;
  • Mackerel;
  • Herring;
  • Tuna;
  • Trout.

For people following a vegetarian or vegan diet, there are plant-based alternatives, such as:

  • Algae oil (source of DHA);
  • Flax seeds;
  • Chia seeds;
  • Walnuts;
  • Soybean oil.

A varied and balanced diet can help ensure adequate intake of these essential nutrients.

Who can benefit from Omega-3 supplements?

Omega-3 supplements can be an option for people with low fish intake or who want to supplement their diet.

They can be considered by people looking to support:

  • Cardiovascular health;
  • Brain function;
  • Eye health;
  • Skin maintenance;
  • Joint health;
  • Overall body balance.

The need for supplementation depends on individual characteristics, diet, and personal goals.

What is the recommended dose of Omega-3?

The appropriate amount of Omega-3 can vary according to individual needs, diet, and specific goals.

It is recommended to follow the manufacturer's instructions for the supplement and seek advice from a healthcare professional when there are specific needs or medical conditions.

What are the side effects of taking Omega-3?

Omega-3 supplements are generally well-tolerated.

Some possible side effects include:

  • Fishy aftertaste;
  • Heartburn;
  • Nausea;
  • Mild digestive disturbances.

People taking anticoagulants, antiplatelets, or other medications that affect coagulation should consult a healthcare professional before starting supplementation.

Can pregnant and breastfeeding women take Omega-3?

DHA is an important nutrient during pregnancy and breastfeeding, contributing to the normal development of the baby's brain and eyes.

However, pregnant or breastfeeding women should seek medical advice before starting any food supplement.

Conclusion

Omega-3 fatty acids are essential nutrients that play an important role in maintaining cardiovascular, brain, and eye health.

A diet rich in fatty fish, plant-based sources of Omega-3, or appropriate supplementation can help ensure sufficient intake of these important fatty acids.

The information presented in this article is for informational purposes only and does not replace medical advice. Food supplements should not be used as substitutes for a varied and balanced diet and a healthy lifestyle.

 

References

1.     

Akintoye, E., Sethi, P., Harris, W.S., Thompson, P.A., Marchioli, R., Tavazzi, L., Latini, R., Pretorius, M., Brown, N.J., Libby, P. and Mozaffarian, D. (2018) 'Fish oil and perioperative bleeding', Circulation: Cardiovascular Quality and Outcomes, 11(11), e004584. https://doi.org/10.1161/CIRCOUTCOMES.118.004584

Bahamondes, M.A., Valdés, C. and Moncada, G. (2021) 'Effect of omega-3 on painful symptoms of patients with osteoarthritis of the synovial joints: Systematic review and meta-analysis', Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 132(3), pp. 297–306. https://doi.org/10.1016/j.oooo.2021.01.020

Begtrup, K.M., Krag, A.E. and Hvas, A.M. (2017) 'No impact of fish oil supplements on bleeding risk: A systematic review', Danish Medical Journal, 64(5), A5366.

Bhatt, D.L., Steg, P.G., Miller, M., Brinton, E.A., Jacobson, T.A. et al. (2019) 'Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia', New England Journal of Medicine, 380(1), pp. 11–22. https://doi.org/10.1056/NEJMoa1812792

Bowman, L., Mafham, M., Wallendszus, K. et al. (2018) 'Effects of n-3 fatty acid supplements in diabetes mellitus', New England Journal of Medicine, 379(16), pp. 1540–1550. https://doi.org/10.1056/NEJMoa1804989

Burdge, G.C., Jones, A.E. and Wootton, S.A. (2002) 'Eicosapentaenoic and docosapentaenoic acids are the principal products of α-linolenic acid metabolism in young men', British Journal of Nutrition, 88(4), pp. 355–364.

Burdge, G.C. and Wootton, S.A. (2002) 'Conversion of α-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women', British Journal of Nutrition, 88(4), pp. 411–420.

Cabiddu, M.F., Russi, A., Appolloni, L., Mengato, D. and Chiumente, M. (2020) 'Omega-3 for the prevention of cardiovascular diseases: Meta-analysis and trial-sequential analysis', European Journal of Hospital Pharmacy. https://doi.org/10.1136/ejhpharm-2020-002207

Carr, J.A. (2018) 'Role of fish oil in post-cardiotomy bleeding: A summary of the basic science and clinical trials', Annals of Thoracic Surgery, 105(5), pp. 1563–1567. https://doi.org/10.1016/j.athoracsur.2018.01.041

Duarte-García, A., Myasoedova, E., Karmacharya, P., Hocaoğlu, M., Murad, M.H., Warrington, K.J. and Crowson, C.S. (2020) 'Effect of omega-3 fatty acids on systemic lupus erythematosus disease activity: A systematic review and meta-analysis', Autoimmunity Reviews, 19(12), 102688. https://doi.org/10.1016/j.autrev.2020.102688

Guo, Y., Ma, B., Li, X., Hui, H., Zhou, Y., Li, N. and Xie, X. (2022) 'Omega-3 polyunsaturated fatty acids can reduce IL-6 and TNF levels in patients with cancer', British Journal of Nutrition. https://doi.org/10.1017/S0007114522000575

Harris, W.S. (2007) 'Expert opinion: Omega-3 fatty acids and bleeding—cause for concern?', American Journal of Cardiology, 99(6A), pp. 44C–46C. https://doi.org/10.1016/j.amjcard.2006.11.021

Harris, W.S. (2007) 'Omega-3 fatty acids and cardiovascular disease: A case for omega-3 index as a new risk factor', Pharmacological Research, 55(3), pp. 217–223. https://doi.org/10.1016/j.phrs.2007.01.013

Institute of Medicine, Food and Nutrition Board (2005) Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids (macronutrients). Washington, DC: National Academy Press.

Jiang, H., Shi, X., Fan, Y., Wang, D., Li, B., Zhou, J., Pei, C. and Ma, L. (2021) 'Dietary omega-3 polyunsaturated fatty acids and fish intake and risk of age-related macular degeneration', Clinical Nutrition, 40(12), pp. 5662–5673. https://doi.org/10.1016/j.clnu.2021.10.005

Jones, P.J.H. and Rideout, T. (2014) 'Lipids, sterols, and their metabolites', in Ross, A.C., Caballero, B., Cousins, R.J., Tucker, K.L. and Ziegler, T.R. (eds.) Modern Nutrition in Health and Disease. 11th edn. Baltimore, MD: Lippincott Williams & Wilkins.

Kavyani, Z., Musazadeh, V., Fathi, S., Faghfouri, H., Dehghan, P. and Sarmadi, B. (2022) 'Efficacy of omega-3 fatty acids supplementation on inflammatory biomarkers: An umbrella meta-analysis', International Immunopharmacology, 111, 109104. https://doi.org/10.1016/j.intimp.2022.109104

Kostoglou-Athanassiou, I., Athanassiou, L. and Athanassiou, P. (2020) 'The effect of omega-3 fatty acids on rheumatoid arthritis', Mediterranean Journal of Rheumatology, 31(2), pp. 190–194. https://doi.org/10.31138/mjr.31.2.190

Kris-Etherton, P.M., Richter, C.K., Bowen, K.J., Harris, W.S. et al. (2019) 'Recent clinical trials shed new light on the cardiovascular benefits of omega-3 fatty acids', Methodist DeBakey Cardiovascular Journal, 15(3), pp. 171–178. https://doi.org/10.14797/mdcj-15-3-171

Manson, J.E., Cook, N.R., Lee, I.M. et al. (2019) 'Marine n-3 fatty acids and prevention of cardiovascular disease and cancer', New England Journal of Medicine, 380(1), pp. 23–32. https://doi.org/10.1056/NEJMoa1811403

Martí Del Moral, A. and Fortique, F. (2019) 'Omega-3 fatty acids and cognitive decline: A systematic review', Nutrición Hospitalaria, 36(4), pp. 939–949. https://doi.org/10.20960/nh.02496

National Institutes of Health, Office of Dietary Supplements (2024) Omega-3 fatty acids – Fact sheet for health professionals. Available at: https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/ (Accessed: 22 July 2026).

Oregon State University, Linus Pauling Institute (2024) Essential fatty acids. Available at: https://lpi.oregonstate.edu/mic/other-nutrients/essential-fattyacids (Accessed: 22 July 2026).

SanGiovanni, J.P. and Chew, E.Y. (2005) 'The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina', Progress in Retinal and Eye Research, 24, pp. 87–138.

Sass, L., Bjarnadóttir, E., Stokholm, J., Chawes, B., Vinding, R.K., Mora-Jensen, A.C. et al. (2021) 'Fish oil supplementation in pregnancy and neurodevelopment in childhood: A randomized clinical trial', Child Development, 92(4), pp. 1624–1635. https://doi.org/10.1111/cdev.13541

Simopoulos, A.P. (2008) 'The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases', Experimental Biology and Medicine, 233(6), pp. 674–688. https://doi.org/10.3181/0711-MR-311

Terry, P.D., Terry, J.B. and Rohan, T.E. (2004) 'Long-chain (n-3) fatty acid intake and risk of cancers of the breast and the prostate: Recent epidemiological studies, biological mechanisms, and directions for future research', Journal of Nutrition, 134(12 Suppl.), pp. 3412S–3420S. https://doi.org/10.1093/jn/134.12.3412S

Theodoratou, E., McNeill, G., Cetnarskyj, R., Farrington, S.M., Tenesa, A., Barnetson, R., Porteous, M., Dunlop, M. and Campbell, H. (2007) 'Dietary fatty acids and colorectal cancer: A case-control study', American Journal of Epidemiology, 166(2), pp. 181–195. https://doi.org/10.1093/aje/kwm063

Thomsen, B.J., Chow, E.Y. and Sapijaszko, M.J. (2020) 'The potential uses of omega-3 fatty acids in dermatology: A review', Journal of Cutaneous Medicine and Surgery, 24(5), pp. 481–494. https://doi.org/10.1177/1203475420929925

Von Schacky, C. (2009) 'Use of red blood cell fatty-acid profiles as biomarkers in cardiac disease', Biomarker Medicine, 3(1), pp. 25–32. https://doi.org/10.2217/17520363.3.1.25

Wood, A.H.R., Chappell, H.F. and Zulyniak, M.A. (2022) 'Dietary and supplemental long-chain omega-3 fatty acids as moderators of cognitive impairment and Alzheimer's disease', European Journal of Nutrition, 61(2), pp. 589–604. https://doi.org/10.1007/s00394-021-02655-4

Zou, R., El Marroun, H., Voortman, T., Hillegers, M., White, T. and Tiemeier, H. (2021) 'Maternal polyunsaturated fatty acids during pregnancy and offspring brain development in childhood', American Journal of Clinical Nutrition, 114(1), pp. 124–133. https://doi.org/10.1093/ajcn/nqab049

Reading next

vitamina D - beneficios para a saude
Alimentacao Saudavel

Leave a comment

This site is protected by hCaptcha and the hCaptcha Privacy Policy and Terms of Service apply.